MSG is a whole lot more than a flavor enhancer

  1. The concept of excitotoxicity, with free glutamate being the principal excitotoxin;
  2. The fact of glutamate-induced brain dam- age followed by obesity;
  3. The abundance of excitotoxic glutamate in processed and ultra-processed foods;
  4. The fact that pregnant females can pass excitotoxic glutamate to their fetuses; and
  5. The correlation between the time that virtually unlimited amounts of free glutamate became available in food and the beginning of the obesity epidemic.
  1. Onaolapo AY, Onaolapo OJ. Dietary glutamate and the brain: In the footprints of a Jekyll and Hyde molecule. Neurotoxicology. 2020;80:93–104.
  2. Morley WA, Seneff S. Diminished brain resilience syndrome: A modern day neurological pathology of increased susceptibility to mild brain trauma, concussion, and downstream neurodegeneration. Surg Neurol Int. 2014;5:97.
  3. Excitotoxicity and cell damage. https://www.sciencedaily.com/terms/excitotoxicity.htm
  4. Blaylock RL. Excitotoxins: The Taste that Kills. Santa Fe, New Mexico: Health Press, 1994.
  5. Teller M. MSG: Three little letters that spell big fat trouble. Wise Traditions. Spring 2017;18(1):42–46.
  6. Morell SF. MSG and free glutamate: Lurking everywhere. https://nourishingtraditions.com/msg-free-glutamate-lurking-everywhere/
  7. Blaylock RL. Excitotoxins, neurodegeneration and neurodevelopment. Available at:
    http://landofpuregold.com/the-pdfs/Excitotoxins.pdf.
  8. Interview with Jodi Ledley. Weston A. Price Foundation, Aug. 10, 2018. https://www.westonaprice.org/health-topics/interview-with-jodiledley/
  9. Global monosodium glutamate market poised to surge from USD 4,500.0 million in 2014 to USD 5,850.0 million by 2020. Market Research Store, Mar. 17, 2016. https:// www.globenewswire.com/news-release/2016/03/17/820804/0/en/Global-Monosodium- Glutamate-Market-Poised-to-Surge-from-USD-4–500–0-Million-in-2014-to-USD- 5–850–0-Million-by-2020-MarketResearchStore-Com.html
  10. Global flavor enhancers market. BCC Research, Dec. 2018. https://www.bccresearch. com/partners/verified-market-research/global-flavor-enhancers-market.html
  11. Global food flavor enhancer market by type (monosodium glutamate (MSG), hydrolyzed vegetable protein (HVP), yeast extract others), by application (restaurants, home cooking, food processing industry) and by region (North America, Latin America, Europe, Asia Pacific and Middle East & Africa), forecast to 2028. Dataintelo, n.d. https://dataintelo. com/report/food-flavor-enhancer-market
  12. Sano C. History of glutamate production. Am J Clin Nutr. 2009;90(3):728S-732S.
  13. Frieder B, Grimm V E. Prenatal monosodium glutamate (MSG) treatment given through the mother’s diet causes behavioral deficits in rat offspring. Int J Neurosci. 1984;23(2):117- 126.
  14. Yu T, Zhao Y, Shi W, et al. Effects of maternal oral administration of monosodium glutamate at a late stage of pregnancy on developing mouse fetal brain. Brain Res. 1997;747(2):195–206.
  15. Nemeroff CB, Crisley FD. Monosodium L-glutamate-induced convulsions: Temporary alteration in blood-brain barrier permeability to plasma proteins. Environ Physiol Biochem. 1975;5(6):389–395.
  16. Benarroch EE. Circumventricular organs: Receptive and homeostatic functions and
    clinical implications. Neurology. 2011;77(12):1198–1204.
  17. Price MT, Olney JW, Lowry OH, Buchsbaum S. Uptake of exogenous glutamate and
    aspartate by circumventricular organs but not other regions of brain. J Neurochem. 1981;36(5):1774–1780.
  18. Broadwell RD, Sofroniew MV. Serum proteins bypass the blood-brain fluid barriers for extracellular entry to the central nervous system. Exp Neurol. 1993;120(2):245–263.
  19. https://www.cdc.gov/breastfeeding/breastfeeding- special-circumstances/vaccinations-medications-drugs/ alcohol.html
  20. Samuels JL. MSG in infant formula. Weston A. Price Foundation, Dec. 31, 2001. https://www.westonaprice. org/health-topics/modern-foods/msg-in-infant-formula/
  21. Olney JW. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science. 1969;164(3880):719–721.
  22. Jais A, Brüning JC. Arcuate nucleus dependent regulation of metabolism pathways to obesity and diabetes mellitus. Endocr Rev. 2022;43(2):314–328.
  23. Burde RM, Schainker B, Kayes J. Monosodium glutamate: necrosis of hypothalamic neurons in infant rats and mice following either oral or subcutaneous administration. J Neuropathol Exp Neurol. 1972;31:181.
  24. Samuels A. The toxicity/safety of processed free glutamic acid (MSG): a study in suppression of information. Account Res. 1999;6(4):259–310.
  25. Hutcherson A. Why you shouldn’t fear MSG, an unfairly maligned and worthwhile seasoning. Washington Post, Aug. 27, 2021.
  26. He K, Zhao L, Daviglus ML, et al. Association of monosodium glutamate intake with overweight in Chinese adults: the INTERMAP study. Obesity (Silver Spring).
    2008;16(8):1875–1880.

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The Truth in Labeling Campaign

The Truth in Labeling Campaign

TLC was incorporated in 1994 as a nonprofit organization dedicated to securing full and clear labeling of all processed food. www.truthinlabeling.org